Where cards are issued to the employees of a business, it is normal for each card to be assigned a fixed limit which will usually be much lower than the global account limit. E.g. total account limit $50,000, with cards issued to ten employees with limits of $5,000 each (or varying limits, but still with a total of $50,000).
It is also possible to limit the kind of expenditure permitted. E.g. a procurement officer may only be allowed to purchase business stock or equipment from certain suppliers, but not use the card for travel and entertainment.